IndraLab

Statements

USP1 activates EZH2. 4 / 4
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"Moreover, depletion of USP1 promoted EZH2 degradation in both U87MG and GSC11 cells, whereas USP1 overexpression increased EZH2 stability (Fig.2 C and D)."
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"Knockdown of USP1 reduces the binding of EZH2 to the promoters of its target genes, as well as H3K27me3 levels of these promoters (Ma et al., 2019)."
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"These results support that USP1 promotes EZH2-mediated gene repression by stabilizing EZH2."
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"These results indicate that EZH2 stabilization mediated by USP1 contributes to β-catenin driven tumorigenesis of gliomas."
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