IndraLab

Statements

PRKG activates KCNMA1. 7 / 7
| 6 1
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"The resulting increase in PKG activity enhanced Ca 2+ spark activity and sufficiently increased BK channel activity to exert an opposing influence on myogenic vasoconstriction."
27729550
sparser
"Mechanistically, PKG has been linked to the activation of the mitochondrial K ATP channel [ xref ] and a recent paper further suggests that PKG activates the cardiomyocyte-specific BK channel at the mitochondria, increasing K + influx into the matrix, opposing mitochondrial Ca 2+ overloading and ROS production [ xref ]."
| PMC
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"With the approach of the present study, especially at lower levels of contractility, NO induces a PKG mediated increase in BK channel activity that is weaker than the large [Ca 2+] i decrease mediated decrease in BK channel activity."
29574460
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"At a high contraction level, NO induces a PKG mediated increase in BK channel activity, well established by many studies,1, 5, 6 that is stronger than the small [Ca 2+] i decrease mediated decrease of BK channel activity."
29574460
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"Mechanistically, PKG has been linked to the activation of the mitochondrial K channel [102] and a recent paper further suggests that PKG activates the cardiomyocyte-specific BK channel at the mitochondria, increasing K influx into the matrix, opposing mitochondrial Ca overloading and ROS production [103]."
| PMC
reach
"Notably, direct application of H 2 O 2 (30 muM) increased Ca 2+ spark frequency in VSMCs from wild-type mice, but did not increase BK channel currents in these same cells treated with ryanodine to block Ca 2+ sparks, further supporting the conclusion that oxidant activated PKG increases BK channel mediated vasodilation of arteries through an increase in Ca 2+ spark frequency rather than a direct effect on the BK channel."
27729550
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"XREF_BIBR, XREF_BIBR PKA, PKG, and PKC also modulate BK channel activity indirectly by modulating the frequency of Ca 2+ sparks generated by sarcoplasmic reticulum ryanodine sensitive Ca 2+ -release channels."
28696251