IndraLab

Statements

USP15 deubiquitinates PRKN. 4 / 4
| 4
reach
"However, we found no evidence that USP15 deubiquitinates Parkin in basal conditions or after exposure to valinomycin (Fig. 5A and B)."
24852371
reach
"At present, the negative regulatory mechanisms against Parkin-mediated ubiquitination have been reported, with the discovery of several deubiquitinases including USP8, USP15 and USP30 that are able to cause the deubiquitination of Parkin and/or OMM proteins."
29934616
reach
"USP15 does not deubiquitylate Parkin under basal conditions or when cells are treated with mitochondrial depolarizing agents."
28959952
reach
"USP15 has been shown to deubiquitinate receptor-activated SMADs and TRIM25 and antagonize Parkin-mediated mitochondrial ubiquitination, and USP15 regulates the TGF-β pathway and is a key factor in glioblastoma pathogenesis (Eichhorn et al., 2012; Pauli et al., 2014; Inui et al., 2011)."
36065190