IndraLab

Statements

USP15 deubiquitinates PRKN. 10 / 10
| 10
reach
"Moreover, both USP15 and USP30 function indirectly, deubiquitinating substrates of PARKIN."
25995186
reach
"It is confirmed that USP15 antagonistically regulates the parkin-mediated mitophagy, but further investigation is required to determine whether the substrates of parkin related to other MOM proteins, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34023421
reach
"USP15 has been shown to deubiquitinate receptor-activated SMADs and TRIM25 and antagonize Parkin-mediated mitochondrial ubiquitination, and USP15 regulates the TGF-β pathway and is a key factor in glioblastoma pathogenesis (Eichhorn et al., 2012; Pauli et al., 2014; Inui et al., 2011)."
36065190
reach
"USP15 Deubiquitinates Parkin Substrates and Inhibits Mitophagy."
36831318
reach
"USP15 does not deubiquitylate Parkin under basal conditions or when cells are treated with mitochondrial depolarizing agents."
28959952
reach
"However, we found no evidence that USP15 deubiquitinates Parkin in basal conditions or after exposure to valinomycin (Fig. 5A and B)."
24852371
reach
"Similarly, the deubiquitinating enzymes USP15 [124], USP33 [63], and USP8 [125] have been shown to antagonize Parkin-mediated mitochondrial ubiquitination and mitophagy."
38931449
reach
"In contrast to USP8, USP15 was unable to deubiquitinate PARKIN; rather, USP15 exerts its effect by deubiquitinating mitochondrial substrates of PARKIN."
25995186
reach
"Thus, USP15 and USP30 both deubiquitinate substrates of PARKIN and oppose PARKIN function in mitophagy."
25995186
reach
"At present, the negative regulatory mechanisms against Parkin-mediated ubiquitination have been reported, with the discovery of several deubiquitinases including USP8, USP15 and USP30 that are able to cause the deubiquitination of Parkin and/or OMM proteins."
29934616