IndraLab

Statements

Mutated BAP1 activates Multiple Myeloma. 4 / 4
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"We recently reported in vivo genetic evidence that germline heterozygous mutation of Bap1 accelerates development of asbestos induced MM."
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"BAP1 is the most promising driver gene in MM pathogenesis, because more than 60% of MM biopsies contain BAP1 mutations and inactivation [XREF_BIBR, XREF_BIBR] and germline BAP1 mutations cause a cancer syndrome with high incidence of MM [XREF_BIBR, XREF_BIBR]."
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"A possible explanation is that germline BAP1 mutations alone can cause MM and many other tumor types."
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"We are investigating how germline BAP1 mutations on one hand promote MM development, while on the other hand they are associated to reduce disease aggressiveness."
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