IndraLab

Statements

EGFR binds SOS, GRB2, and SHC. 6 / 6
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"HO also induces the association of the Shc-Grb2-Sos complex with the EGF receptor, resulting in activation of downstream signalling systems ."
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"After EGFR activation, a trimeric complex between tyrosine phosphorylated Shc, Grb2, and Sos is formed and this, in turn, triggers downstream mitogenic signaling xref ."
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"Once the SHC-Grb2-SOS complex is associated with the EGFR, the SOS promotes the exchange of GDP for GTP on Ras, a small G protein."
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"The Grb2-SOS complexes that have bound to EGFR or the EGFR-Shc complex catalyse the conversion of RasGDP to RasGTP (reaction 28), whereas the reverse transition is catalysed by RasGAP bound to the RP 2 form of EGFR (reaction 29)."
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"Our subsequent studies demonstrated that during experimental gastric ulcer healing, EGF-R associates with the adapter proteins, Grb2, Shc, and the guanidine nucleotide exchange factor SOS, leading to activation of Raf-1 kinase [27]."
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"The activated EGFR binds to the SHC-Grb2-SOS complex and further stimulates the RAS-Raf-MEK-ERK signaling pathway, acting on receptors in the nucleus, such as STAT3, AP-1 ( xref )."
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