IndraLab

Statements

SHC binds SOS, EGFR, and GRB2. 5 / 5
| 5
sparser
"The Grb2-SOS complexes that have bound to EGFR or the EGFR-Shc complex catalyse the conversion of RasGDP to RasGTP (reaction 28), whereas the reverse transition is catalysed by RasGAP bound to the RP 2 form of EGFR (reaction 29)."
22340367
sparser
"The activated EGFR binds to the SHC-Grb2-SOS complex and further stimulates the RAS-Raf-MEK-ERK signaling pathway, acting on receptors in the nucleus, such as STAT3, AP-1 ( xref )."
33681289
sparser
"HO also induces the association of the Shc-Grb2-Sos complex with the EGF receptor, resulting in activation of downstream signalling systems ."
10206339
sparser
"Once the SHC-Grb2-SOS complex is associated with the EGFR, the SOS promotes the exchange of GDP for GTP on Ras, a small G protein."
29548337
sparser
"After EGFR activation, a trimeric complex between tyrosine phosphorylated Shc, Grb2, and Sos is formed and this, in turn, triggers downstream mitogenic signaling xref ."
23527181