IndraLab

Statements


SHC binds SOS, EGFR, and GRB2. 4 / 4
| 4
sparser
"The Grb2-SOS complexes that have bound to EGFR or the EGFR-Shc complex catalyse the conversion of RasGDP to RasGTP (reaction 28), whereas the reverse transition is catalysed by RasGAP bound to the RP 2 form of EGFR (reaction 29)."
sparser
"HO also induces the association of the Shc-Grb2-Sos complex with the EGF receptor, resulting in activation of downstream signalling systems ."
sparser
"Once the SHC-Grb2-SOS complex is associated with the EGFR, the SOS promotes the exchange of GDP for GTP on Ras, a small G protein."
sparser
"After EGFR activation, a trimeric complex between tyrosine phosphorylated Shc, Grb2, and Sos is formed and this, in turn, triggers downstream mitogenic signaling xref ."