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PYR41 inhibits ITCH. 2 / 2
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"We therefore did not follow up clomipramine.Performing IC 50 inhibition curves using the MALDI-TOF E2/E3 assay, we could show that PYR41 inhibited MDM2, ITCH, and HOIP at IC 50 values of 3.1, 11.3, an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Performing IC 50 inhibition curves using the MALDI-TOF E2/E3 assay (XREF_FIG; XREF_SUPPLEMENTARY), we could show that PYR41 inhibited MDM2, ITCH, and HOIP at IC 50 values of 3.1, 11.3, and 5.7 muM."