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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

Nuclear L DI-DII activates SCN5A. 1 / 1

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"In this addendum to our study, we report our observations that 1) the linker between domains I and II (L DI-DII) of Na V 1.5 contains a nuclear localization signal (residues 474-481) that is necessary to localize L DI-DII into the nucleus, and 2) nuclear L DI-DII activates the SCN5A promoter in gene reporter assays using cardiac like H9c2 cells."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...