IndraLab

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USP30 inhibits MFN1. 3 / 3
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"For example, based on a phenotypic screening, it was shown that the inhibition of USP30 by the compound 15-oxospiramilactone enhances the activity of USP30 's targets Mfn1 and Mfn2 -- two GTPases anchored at the OMM and essential for tethering adjacent mitochondria -- and promotes mitochondrial fusion, thus contributing to the restoration of the mitochondria network [XREF_BIBR]."
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"S3 induced inhibition of USP30, a mitochondrial localized deubiquitinase, increased the ubiqutinylation of MFN1 and MFN2 without affecting their protein levels."
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"Inhibition of USP30 leads to increased non-degradative ubiquitination of Mfn1/2, thereby enhancing the activity of Mfn1 and Mfn2, and promoting mitochondrial fusion [ 23 ]."
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