IndraLab

Statements

PSMD14 binds SMAD3. 9 / 9
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"Co-immunoprecipitation (Co-IP) showed that POH1 interacted with Smad3 ( Fig. 1 B); the other two did not."
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"Next, we determined whether POH1 physically interacts with Smad3."
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"Altogether, this demonstrated a direct interaction between POH1 and Smad3, a previously unknown molecular association.Given that POH1 interacts with Smad3 and promotes its stability in the aforementio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To further prove the direct interaction between POH1 and Smad3, a proximity ligation assay (PLA), which is a newly developed technique for visualizing endogenous protein-protein interactions in situ ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, endogenous POH1 and Smad3 were strongly associated in the Co-IP assay ( Fig. 3 B)."
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"To further prove the direct interaction between POH1 and Smad3, a proximity ligation assay (PLA), which is a newly developed technique for visualizing endogenous protein-protein interactions in situ ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in Fig. 3 D, PLA signals were remarkably intensified in H1299 cells stained with POH1 and Smad3 antibodies, whereas PLA signals were marginally visible in control cells, strongly suggesting t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, it is highly reasonable to presume that the activation of POH1-Smad3 signaling enhances NSCLC growth and metastasis by stabilizing Smad3 and strengthening Smad3-related cellular functions."
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"Altogether, this demonstrated a direct interaction between POH1 and Smad3, a previously unknown molecular association."
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