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EGF leads to the phosphorylation of PTK2 on tyrosine. 22 / 22
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"Our results support the conclusion that p21 rho is important for the ability of EGF to stimulate tyrosine phosphorylation in pancreatic acini because C3 transferase pretreatment markedly inhibited EGF[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Treatment of pancreatic acini with cytochalasin D completely inhibited tyrosine phosphorylation of p125 FAK, p130 Cas, and paxillin stimulated by CCK-8 and EGF in rat pancreatic acini [13,23,42]."
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"In the present study we found that cytochalasin D, which disrupts the integrity of the actin cytoskeleton [38], completely inhibited EGF stimulated p125 FAK and paxillin tyrosine phosphorylation in pa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Two recent studies in other tissues [19,20] report that EGF can also stimulate tyrosine phosphorylation of p125 FAK and paxillin, suggesting it could be an important signaling cascade for the EGF rece[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, pretreatment of pancreatic acini with 100 muM LY294002 for 1 h caused a 49 +/-12% and 47 +/-14% decrease in the tyrosine phosphorylation of p125 FAK and paxillin by EGF (10 nM), respectively[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To determine whether PKC activation might be involved in mediating the EGF stimulated changes in p125 FAK and paxillin tyrosine phosphorylation, we examined the effect of a PKC inhibitor, GF109203X [3[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, the fact that EGF stimulates PLCgamma activity raises the possibility that PKC activation or calcium mobilization could be possible mediators of EGF stimulation of p125 FAK and paxillin tyr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In contrast, EGF or PDGF did not stimulate the tyrosine phosphorylation of FAK."
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"XREF_BIBR - XREF_BIBR Here, we stress our new finding in this experiment that EGF caused tyrosine phosphorylation of FAK (Y397) and p130cas (Y410), and Fn caused general phosphorylation of ERK, which were neglected before."
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"However, given that pY-β-PIX/FAK/paxillin in Src inhibitor-treated podocytes was blunted basally but remained partially responsive to EGF stimulation, it is likely that Src is not the sole regulator of the signaling pathway responsible for EGF-mediated tyrosine phosphorylation of β-PIX, FAK, and paxillin.Collectively, our findings support a model wherein CdGAP interacts with β-PIX in the cytoplasm and contributes to maintaining low Rac1/Cdc42 activity at basal conditions."
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"Thus, in rat pancreatic acini the phosphorylation of p125 FAK and paxillin by EGF depends on the integrity of the actin cytoskeleton.In summary, we found that EGF causes a rapid, concentration depende[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pretreatment with cytochalasin D completely inhibited EGF stimulated p125 FAK and paxillin tyrosine phosphorylation."
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"The fact that the tyrosine phosphorylation of p125 FAK and paxillin resulted from specific EGF receptor interaction was supported by the fact that EGF induced a rapid increase in the tyrosine phosphor[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, GF109203X pretreatment did not modify EGF stimulated p125 FAK and paxillin tyrosine phosphorylation or basal tyrosine phosphorylation in control cells in the absence of EGF."
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"Activation of PI3-kinase and the small GTP binding protein, p21 rho, are involved in EGF stimulated phosphorylation because pretreatment with wortmannin, LY294002 or with C3 transferase inhibited EGF [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We used mass spectrometry-based proteomics to comprehensively compare proteins that were tyrosine phosphorylated in response to EGF and PDGF and their associated partners. More than 90% of these signaling proteins were used by both ligands, whereas the phosphatidylinositol 3-kinase (PI3K) pathway was exclusively activated by PDGF,"
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"This conclusion is established by demonstrating that pretreatment of pancreatic acini with the PKC inhibitor GF109203X, at a concentration that has been shown previously to completely inhibit TPA stim[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The dose response curves for EGF stimulation of tyrosine phosphorylation of p125 FAK and paxillin were similar to the ability of EGF to cause receptor occupation in rat pancreatic acini [1], demonstra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The focal adhesion proteins paxillin and p125FAK were tyrosine phosphorylated in response to bradykinin but not in response to epidermal growth factor."
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"Furthermore, an increase in the calcium influx had no effect on EGF stimulation of the tyrosine phosphorylation of p125 FAK and paxillin."
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"To determine whether PI3-kinase activation might be involved in mediating the EGF stimulation of p125 FAK and paxillin tyrosine phosphorylation in pancreatic acini, we examined the effect of a two unr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"EGF stimulates tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin in rat pancreatic acini by a phospholipase C independent process that depends on phosphatidylinositol 3-kinase, the small GTP binding protein, p21rho, and the integrity of the actin cytoskeleton."
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