IndraLab

Statements

FBXO32 inhibits EIF3F. 11 / 11
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"Genetic repression of eIF3f in differentiated skeletal muscle is sufficient to induce atrophy XREF_BIBR and degradation of eIF3f by MAFbx suppresses S6K1 activation by mTOR."
20126553
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"The silencing of MAFbx expression by small hairpin RNA interference prevents eIF3f degradation in myotubes undergoing atrophy [XREF_BIBR]."
23354061
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"In addition, recent studies indicate that under atrophic conditions, atrogin-1 can directly regulate mTORC1 signalling and protein synthesis via the ubiquitination and subsequent degradation of eIF3f."
21821120
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"Furthermore, berberine, an inhibitor of mitochondrial respiration, induces atrophy through MAFbx/atrogin-1-mediated degradation of eIF3f in a mice model of type 2 diabetes (Wang et al., 2010)."
23769948
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"Proteasomal degradation of eIF3f mediated by the overexpressed MAFbx/atrogin-1 under starvation and diseases is leading to decreased protein synthesis and muscle wasting."
23769948
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"Evidences indicate that increase of MAFbx in response to food deprivation causes eIF3f loss, leading to marked decrease on phosphorylation of p70 S6K, without alterations in mTOR activity, indicating the association of mTOR downstream targets [XREF_BIBR]."
27647951
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"Our data are consistent with a model whereby alcohol increases proteolysis via FOXO independent increase in atrogin-1, which degrades eIF3f and therefore impairs formation of a functional preinitiation complex and protein synthesis."
24226028
eidos
"Of note , a subset of microRNAs ( miRNAs ) in the delta-like homolog 1 and the type III iodothyronine deiodinase ( Dlk1-Dio3 ) cluster showed an anti-atrophic effect , probably by limiting the degradation of eIF3f by MAFbx / atrogin-1 [ 168 ] ."
| PMC
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"Furthermore, berberine, an inhibitor of mitochondrial respiration, induces atrophy through MAFbx and atrogin-1-mediated degradation of eIF3f in a mice model of type 2 diabetes."
23769948
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"Degradation of eIF3f by MAFbx Suppresses S6K1 Activation by mTOR."
20126553
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"In addition, expression of a protein Fbxo32, which degrades MyoD and eIF3-f in skeletal muscle, was also increased in muscle of CTG550 mice."
23796888