IndraLab

Statements

CYLD inhibits DDX58. 8 / 9
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"USP3, USP21 and CYLD inhibit RIG-I K63-linked ubiquitination and activation."
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"For example, the 3C protein of enterovirus 71 (EV71), a member of the Picornaviridae family that causes hand, foot and mouth disease, and occasionally severe central nervous system diseases, downregulates the host microRNA miR-526a to increase the expression of the cellular DUB enzyme CYLD, thus inhibiting the activation of RIG-I 74."
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"For example, the 3C protein of enterovirus 71 (EV71), a member of the Picornaviridae family that causes hand, foot and mouth disease, and occasionally severe central nervous system diseases, downregulates the host microRNA miR-526a to increase the expression of the cellular DUB enzyme CYLD, thus inhibiting the activation of RIG-I ."
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"Conversely, the removal of Lys63 linked ubiquitylation by the cellular deubiquitylating enzymes (DUBs) ubiquitin C-terminal hydrolase 3 (USP3), USP21 and CYLD, represses RIG-I signalling."
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"XREF_BIBR, XREF_BIBR Conversely, CYLD, a tumor suppressor gene expressed in cylindromatosis, negatively regulates RIG-I activation by deubiquitinating the K63 linked ubiquitin chains on RIG-I."
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"The tumor suppressor CYLD (cylindromatosis), another OTU de-ubiquitinating enzyme that removes Lys 63 linked polyubiquitin chains, was also recently shown to negatively regulate RIG-I."
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"Conversely, the removal of Lys63-linked ubiquitylation by the cellular deubiquitylating enzymes (DUBs) ubiquitin C-terminal hydrolase 3 (USP3), USP21 and CYLD, represses RIG-I signalling (reviewed in Ref."
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"Another ubiquitin ligase RNF135 (also known as Riplet) is similarly involved in the positive regulation of RIG-I signaling, while RNF125 and the deubiquitinase CYLD are known to negatively regulate RIG-I signaling."
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