Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OTULIN leads to the dephosphorylation of CYLD on S418. 1 / 1

| 1

➶

reach

"Another NF-κB inhibitory DUB, OTULIN inhibits Ser418 phosphorylation of CYLD through a LUBAC-dependent mechanism, which sustains its catalytic activity, while hyperphosphorylation of OUTLIN at Tyr56 regulates necroptosis by modulating RIPK1 ubiquitin dynamics [30]."

32512887

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...