IndraLab
Statements
reach
"In GM-CSF-supplemented culture, over-expression of Usp18 restored the development of CD11b + CD11c + cells in Usp18 deficient BM cells, but did not affect DC development in wild-type BM cells (XREF_FIG), which confirmed the notion that the development defect of BM-DCs is intrinsic to Usp18 deficient cells."
reach
"Usp18 (-/-) BM cells were rescued by exogenous expression of either wild-type or deconjugation-inactive Usp18, and superimposition of an IFN-alpha and beta receptor knockout returned in vivo DC populations to normal, clearly showing that the defect seen is due solely to Usp18 's effect on IFN signaling."