IndraLab

Statements

USP18 activates USP18. 5 / 6
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"In human cells, USP18 conjugating to ISG15 increased the level of USP18 by preventing the degradation of USP18, and further strengthened the inhibition of IFN receptor signal."
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"In GM-CSF-supplemented culture, over-expression of Usp18 restored the development of CD11b + CD11c + cells in Usp18 deficient BM cells, but did not affect DC development in wild-type BM cells (XREF_FIG), which confirmed the notion that the development defect of BM-DCs is intrinsic to Usp18 deficient cells."
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"The process of de-ISGylation, which removes ISG15 from the target protein, is mediated by the enzyme ubiquitin-specific peptidase 18 (USP18) [3]."
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"All these results indicated that HOXA5 is directly bound to the promoter of USP18 and activated USP18 transcription.3.6 Overexpressing USP18 Could Abolish the Effects of HOXA5 Knockdown on Cell Development and DDP Resistance in DDP-Resistant ESCC cells."
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"Pretreatment with IFNβ led to increased levels of IRF3 activation by dsDNA90 treatment in all cell sublines.IFNβ pretreatment but not dsDNA90 increased USP18 levels in parental FTE-194 cells and UBA7-null cells, but not in ISG15-null cells (Fig. 3), likely reflecting the importance of free ISG15 in stabilizing USP18."
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