IndraLab

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PSMD14 activates HYCC1. 13 / 13
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"The reciprocal effects of knockdown and overexpression of PSMD14 in vitro suggested that PSMD14 enhanced the proliferation ability of HCC cells."
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"Functionally, POH1 intensifies TGF-beta signaling delivery and, as a consequence, promotes HCC cell metastatic properties both in vitro and in vivo."
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"PSMD14 is known to enhance HCC progression and metastasis by stabilizing GRB2 [41]."
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"We found that POH1 knockdown significantly reduced the migration and invasion capability of HCC cells (Fig. 6a)."
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"PSMD14 can promote phenotypic changes in HCC cells in vitro, including affecting cell proliferation invasion and migration."
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"In contrast, overexpression of POH1 significantly accelerated TGF-β-induced migration and invasion of HCC cells tested by transwell and wound healing assays (Fig. S5a-b), without altering the growth rate in vitro (Fig. S5c)."
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"Also, PSMD14 promoted HCC cell and tumor growth while inducing cell migration and tumor metastasis in in-vitro and in-vivo by stabilizing GRB2 via deubiquitylation ( Lv et al., 2020 )."
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"Nevertheless, we found that knockdown of PSMD14 led to an obvious decrease in the proliferation capacity of Hep3B cells (p53 deficient), indicating that PSMD14 promoted the proliferation of HCC cells [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Collectively, these data demonstrated that PSMD14 promoted HCC growth both in vitro and in vivo ."
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"Concurrently, gene set enrichment analyses of the TCGA and several GEO liver cancer datasets demonstrated a significant enrichment in the expression of a set of genes, which indicates poor survival of patients [32], in HCCs with high POH1 expression (Fig. S2b).3.2 POH1 promotes TGF-beta signaling in HCC cells."
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"POH1 can remove the K63-polyubiqutin chains attached to CAV1 and compromise its activity in the lysosomal degradation of the TGF-β receptors.Regarding the functional consequences of POH1-mediated promotion of TGF-β signaling in HCC cells, we found that POH1 substantially increased the metastatic potential of HCC cells both in vitro and in vivo."
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"Here, our findings showed that PSMD14 promoted in vitro proliferation, migration, and invasion of HCC cells, and facilitated tumor growth and metastasis in vivo ."
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"In addition, PSMD14 can promote phenotypic changes in HCC cells in vitro, fostering cell proliferation invasion and migration."
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