IndraLab

Statements

USP9X activates APC_C. 3 / 3
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"USP9X thereby opposes activation of anaphase promoting complex and cyclosome (APC/C) and specifically inhibits the mitotic degradation of SAC controlled APC/C substrates."
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"The deubiquitinase USP9X modulates the stability of MCC : APC/C complex thereby influencing the SAC dynamics."
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"This suggests that maintenance of CEP55 and CEP131 is the major factor contributing to reduced cell survival following relatively high-LET protons in the absence of USP9X.Our findings that USP9X does not affect cell cycle progression is in agreement with a previous study, which demonstrated that USP9X depletion was linked to an increased loss of anaphase-promoting complex/cyclosome (APC/C) substrates, in particular cyclin A, but also cyclin B and NEK2A, and that cells consequently failed to arrest mitosis after microtubule poisoning in HeLa cells and U2OS cells (35)."
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