
IndraLab
Statements
HCN4 phosphorylates phospholamban. 1 / 1
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1
reach
"To explain the restored maximal beating rate in response to maximal phosphodiesterase (PDE) inhibition, autonomic receptor stimulation, or infused cyclic adenosine monophosphate (cAMP), the model predicts that phospholamban phosphorylation by protein kinase A (PKA) and HCN 4 sensitivity to cAMP are altered in advanced age."