IndraLab

Statements

TEA inhibits KCNMA1. 13 / 13
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"BK channel antagonist TEA has been reported to inhibit cell proliferation, for example, preventing mitogen stimulated quiescent lymphocytes from becoming rapidly cycling tumor cells."
25700359
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"A similar inhibition of the channels was observed with the BK channel blockers TEA, 4-AP and charybdotoxin (CTX) (Wyatt and Peers, 1995)."
16137743
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"Inneitherthisnorourprevious study (Mienville and Clay, 1996) was this type of effect observedwithNMG.Alternatively, veryfastblockratescan berecorded as areductioninchannelconductance, as with TEA bloc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8994603
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"Demo and Yellen 1992 found that BK channel block by either internal Cs + or external TEA had no effect on P o, and they concluded that Cs + could occupy at least two sites in the pore, only one of which affects gating."
10436004
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"Because maxi-K + channels are blocked by TEA or IbTX, we tested to see whether, like hypoxia, addition of these agents to the external solution induces Ca 2+ entry and secretion from glomus cells.In m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12126696
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"We have demonstrated that TEA and IBTX inhibit the BK channel currents by the same extent of 53% in uterine arterial myocytes XREF_BIBR."
25013368
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"Blockade of Slo1 by TEA is thought to involve occupancy of the BK channel central cavity, although some features of block of Slo1/BK channels by quaternary ammonium blockers supports block of both closed and open channels."
19934650
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"However, for comparison to block of Slo1 by TEA i, 0.5-2 mM is probably a reasonable estimate of an upper limit for the 0-voltage affinity of TEA to its blocking site."
19934650
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"In contrast, tetraethylammonium (TEA) and iberiotoxin (IBTX), which block Slo1 but not Slo3, neither affected I KSper nor V m of human sperm (XREF_FIG)."
24670955
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"XREF_BIBR, XREF_BIBR 250 muM TEA blocked Slo1 current about 50% at 0 mV with block being relieved at more positive potentials (XREF_FIG)."
19934650
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"Subsequently, using isometric tension recording and vascular reactivity techniques along with BK channel specific pharmacological blockers such as tetraethylammonium (TEA), charybdotoxin and iberiotoxin, several studies demonstrated enhanced function of BK channels in arteries of experimental hypertensive animals [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
23376354
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"Application of 80 mM TEA to the cytoplasmic side decreased the macroscopic hSlo current at 140 mV to ~ 10% of the control level."
11222629
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"Qualitatively, block of MC13 by TEA i exhibited features quite distinct from block of Slo1 by TEA i."
19934650