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TEA inhibits KCNMA1. 23 / 23
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"Because maxi-K + channels are blocked by TEA or IbTX, we tested to see whether, like hypoxia, addition of these agents to the external solution induces Ca 2+ entry and secretion from glomus cells.In m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Highlighting the important contribution to UtA blood flow, the in vivo infusion of the BK channel blocker TEA decreased UtA blood flow in pregnant sheep [38]."
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"In contrast, tetraethylammonium (TEA) and iberiotoxin (IBTX), which block Slo1 but not Slo3, neither affected I KSper nor V m of human sperm (XREF_FIG)."
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"The blockade of the BK channel with iberiotoxin or tetraethylammonium (TEA) induces membrane depolarization, followed by an elevation of [Ca ] , vasoconstriction, and elevated blood pressure [42,108,109,110]."
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"In vascular smooth muscle, MaxiK channels were significantly inhibited by external TEA ( K d = 150–300 μM) and IbTX (IC50 ∼ 250 pM) ( Galvez et al., 1990 )."
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"Thus, at the concentrations used in the present study, TEA (5 × 10 −3 M) and IbTX (10 −7 M) should preferentially block MaxiK channels."
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"We have demonstrated that TEA and IBTX inhibit the BK channel currents by the same extent of 53% in uterine arterial myocytes XREF_BIBR."
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"In an RA rat model, KCa1.1 channel blockers such as paxilline, TEA, and iberiotoxin were used to block the channel activity, which resulted in an approximately 80% blockage of potassium currents by TEA and paxilline (Tanner et al., 2015; 2018)."
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"Furthermore, the BK channel blocker TEA has been shown to decrease basal uterine blood flow, inhibit K currents, and increase pressure-dependent vascular tone in pregnant sheep (Rosenfeld et al., 2001; Rosenfeld et al., 2005; Hu et al., 2011)."
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"Inneitherthisnorourprevious study (Mienville and Clay, 1996) was this type of effect observedwithNMG.Alternatively, veryfastblockratescan berecorded as areductioninchannelconductance, as with TEA bloc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Demo and Yellen 1992 found that BK channel block by either internal Cs + or external TEA had no effect on P o, and they concluded that Cs + could occupy at least two sites in the pore, only one of which affects gating."
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"Application of 80 mM TEA to the cytoplasmic side decreased the macroscopic hSlo current at 140 mV to ~ 10% of the control level."
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"TEA was reported earlier to enhance mineralization at a 0.1–3 mM concentration range in primary osteoblasts, where TEA blocks the large conductance Ca -activated K channel, KCa1.1 [13]."
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"Previously, TEA, 4-AP, and quinidine were reported to block mouse Slo-1 channels, where 250 μM TEA, 25 mM 4-AP, or 100 μM quinidine blocked the Slo1 current by 50% at 0 mV ( Tang et al., 2010 )."
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"A similar inhibition of the channels was observed with the BK channel blockers TEA, 4-AP and charybdotoxin (CTX) (Wyatt and Peers, 1995)."
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"XREF_BIBR, XREF_BIBR 250 muM TEA blocked Slo1 current about 50% at 0 mV with block being relieved at more positive potentials (XREF_FIG)."
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"Qualitatively, block of MC13 by TEA i exhibited features quite distinct from block of Slo1 by TEA i."
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"However, for comparison to block of Slo1 by TEA i, 0.5-2 mM is probably a reasonable estimate of an upper limit for the 0-voltage affinity of TEA to its blocking site."
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"Subsequently, using isometric tension recording and vascular reactivity techniques along with BK channel specific pharmacological blockers such as tetraethylammonium (TEA), charybdotoxin and iberiotoxin, several studies demonstrated enhanced function of BK channels in arteries of experimental hypertensive animals [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
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"At these concentrations, TEA blocks delayed rectifier and BK channel currents responsible for spike repolarization and the fast AHP (Storm, 1987) , whereas 4AP blocks the D-current (Storm, 1988) ."
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"BK channel antagonist TEA has been reported to inhibit cell proliferation, for example, preventing mitogen stimulated quiescent lymphocytes from becoming rapidly cycling tumor cells."
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"Blockade of Slo1 by TEA is thought to involve occupancy of the BK channel central cavity, although some features of block of Slo1/BK channels by quaternary ammonium blockers supports block of both closed and open channels."
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"TEA (tetraethylammonium) and paxilline were used to inhibit the KCa1.1 K current."
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