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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

YOD1 binds K11-and and K33. 1 / 1

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"Article Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets.Highlights d Protease-resistant diUb probes bind to DUB S1-S2 sites and react at the proximal end d First kinetic assay showing proximal end cleavage by DUBs using diUb-based substrates d OTUD3 binds K11-linked diUb and OTUD2 binds K11-and K33-linked diUb in S1-S2 pockets d Kinetics suggest different mechanisms for polyUb cleavage by OTUD2 and OTUD3 SUMMARY Ubiquitin chains are important post-translational modifications that control a large number of cellular processes."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...