IndraLab

Statements

E3_Ub_ligase ubiquitinates RAC1. 4 / 4
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"XREF_BIBR While Smurf1 and Cullins (Cul3) were shown to regulate the polyubiquitination and degradation of RhoA, the E3 ligases driving Rac1 polyubiquitination were not known."
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"For example, K197 is equivalent to K166 in Rac1, which is polyubiquitinated by an SCF family E3 ligase [29]."
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"The E3 Ubiquitin-Ligase HACE1 907 Catalyzes the Ubiquitylation of Active Rac1."
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"It has been well documented that Rac1 is ubiquitylated by E3 proteins HACE, XIAP, and c-IAP1 on K147, and by FBXL19 on K166 dependent on S71 phosphorylation [ xref , xref , xref ]."
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