
IndraLab
Statements
USP18 activates Refractory. 2 / 2
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2
✎
eidos
"However , we have also found that USP18 is necessary but not sufficient on its own to induce an IFN - refractory state ( 53 ) ."
✎
eidos
"It was shown that USP18 is responsible to induce this refractory state as USP18-deficient mice ( FVB background ) and cells do exhibit this kind of desensitisation after repeated injections of IFNalpha [ 5,46 ] ."