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USP18 activates Refractory. 2 / 2

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"However , we have also found that USP18 is necessary but not sufficient on its own to induce an IFN - refractory state ( 53 ) ."

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eidos

"It was shown that USP18 is responsible to induce this refractory state as USP18-deficient mice ( FVB background ) and cells do exhibit this kind of desensitisation after repeated injections of IFNalpha [ 5,46 ] ."

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USP18 activates Refractory. 2 / 2

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