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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP18 activates Refractory. 2 / 2

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"However , we have also found that USP18 is necessary but not sufficient on its own to induce an IFN - refractory state ( 53 ) ."

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"It was shown that USP18 is responsible to induce this refractory state as USP18-deficient mice ( FVB background ) and cells do exhibit this kind of desensitisation after repeated injections of IFNalpha [ 5,46 ] ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...