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Alpha beta-unsaturated carbonyl prostaglandins inhibits ZUP1. 1 / 1
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eidos
"USP5 / 7/8/13 / 14/15/22 Inhibitors Inspired by the discovery that the alpha , beta-unsaturated carbonyl in prostaglandins could react with the catalytic cysteine of DUBs to form covalent bonds and result in the inhibition of the DUBs , curcusone D ( Figure 12 ) was reported as a novel USPs inhibitor [ 127 ] ."