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"37 Relevant to the present discussion, down-regulation of miR-1 and miR-133 have been associated with increased protein levels of HCN2 and HCN4 in hypertrophic hearts, whereas transfection of miR-1 and miR-133 into angiotensin II stimulated neonatal cardiac myocytes prevented overexpression of HCN2 and HCN4."