IndraLab

Statements

MiR-9 activates KCNMA1. 4 / 4
| 4
reach
"Interestingly, miR-9 also targets the BK channel (large conductance calcium- and voltage activated potassium channel) and selectively destabilizes splice variants, resulting in downregulation of the alcohol specific splice variant."
25175860
reach
"An elegant study by Pietrzykowski and colleagues showed that miR-9, upregulated upon exposure to ethanol, specifically targets a subset of BK channel splice variants that contain miR-9 MREs in their 3 '-UTRs in rat supraoptic nucleus explants."
22394481
reach
"107 Intriguingly, miR-9 preferentially targets and degrades transcripts of BK channel isoforms sensitive to alcohol potentiation, whereas transcripts encoding alcohol-tolerant channels tend to lack miR-9-binding sites in their 3 '-UTRs."
21606928
reach
"Alcohol up-regulates miR-9, which targets the BK channel subunits, leading to post-transcriptional reorganization of BK splice variants and resulting in down-regulation of the specific splice variant that is sensitive to alcohol."
25565954