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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNMA1 activates nitric oxide. 2 / 2

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"In nerve terminals of the posterior pituitary, NO increases BK channel conductance, generating spike after hyperpolarization and also Na + channels recovery from inactivation, so reducing action potential failures."

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"Stimulation of BK channel activity by the nitric oxide (NO)/soluble guanylate cyclase (sGC)/cGMP-dependent protein kinase (PKG) pathway, which is important in mediating the effects of endothelial dependent vasodilators, is not thought to be involved in modulating the myogenic response of small resistance arteries during basal tone because there is no evidence for pressure induced release of NO from the endothelium XREF_BIBR - XREF_BIBR."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...