IndraLab

Statements

SCN5A binds PSMD4. 8 / 8
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"We hypothesized that early-onset lone AF was associated with genetic variation in SCN5A. The coding sequence of SCN5A was sequenced in 192 patients with early-onset lone AF."
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"It is, however, noteworthy that SCN5A mutations have been associated with AF in patients with Brugada [ xref ]."
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"14 Finally, two very recent publications have demonstrated that SCN5A mutations are associated with AF, both in isolated forms 15,16 and in patients with underlying heart disease."
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"For example, variations in the gene SCN5A, which is associated with lone AF [ xref ], have shown to accelerate the process of ventricular fibrosis [ xref ] that may in turn be responsible for a prolonged QRSd."
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"One loss of function variant was identified in the cardiac sodium channel, SCN5A that resulted in reduced peak sodium current density and has previously been associated with AF."
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"There are mutations or rare variants in SCN5A that have been associated with familial AF [ xref , xref ]."
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"However, mutations in genes other than SCN5A have also been associated with AF, including SCN10A and SCN1B ."
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"These results indicate that a defect in the SCN5A gene is not associated with AF events or with VF events as was previously reported ( 1 ), suggesting that genetic analysis is not useful for risk st[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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