IndraLab

Statements

Guanosines inhibits PAN2. 5 / 5
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"We found that 3′ guanosines can strongly inhibit S. cerevisiae and H. sapiens Pan2–Pan3 and S. pombe Ccr4–Not in a fully reconstituted in vitro system (Fig. 1b-c, Fig. 2b)."
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"On the other hand, guanosines or dihydrouracils strongly inhibit Pan2 and Caf1 as they are unable to adopt the stacked, helical structure of poly(A) RNA."
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"3' guanosines inhibit the Pan2 exonuclease."
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"To understand why guanosines inhibit Pan2, we soaked AAGGA or AAGGAA RNAs into Pan2 crystals, which diffracted to 3."
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"Together, these data suggest that guanosines disrupt the stacked, helical conformation of poly(A) in the Pan2 active site."
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