IndraLab

Statements

RBBP8 binds PAN2. 9 / 9
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"As shown in Supplementary Fig.  xref and Fig.  xref , WT USP52, but not the USP52 ΔWD40 truncate, successfully rescued DSB resection and HR in USP52-depleted cells, suggesting that the USP52–CtIP interaction is important for the role of USP52 in DSB resection and HR."
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"This further confirms the interaction between USP52 and CtIP in cells."
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"Interestingly, the interaction between USP52 and CtIP did not change with IR treatment (Supplementary Fig.  xref ), suggesting their interactions are not DNA damage inducible."
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"As shown in Fig.  xref , the N-terminal region (AA17–AA160) of CtIP and the WD40 domain of USP52 are indispensable for the interaction between CtIP and USP52."
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"USP52 directly interacts with and deubiquitylates CtIP to promote DNA end resection and HR [118]."
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"Because the interaction between CtIP and USP52 was not changed before or after IR treatment, it is possible that the phosphorylation of USP52 increases its catalytic capability but not the affinity toward CtIP."
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No evidence text available
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