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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNMA1 activates PRKG. 1 / 1

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"Notably, direct application of H 2 O 2 (30 muM) increased Ca 2+ spark frequency in VSMCs from wild-type mice, but did not increase BK channel currents in these same cells treated with ryanodine to block Ca 2+ sparks, further supporting the conclusion that oxidant activated PKG increases BK channel mediated vasodilation of arteries through an increase in Ca 2+ spark frequency rather than a direct effect on the BK channel."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...