IndraLab

Statements

ESRRB activates USP17L2. 4 / 4
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reach
"As expected, only wild type Esrrb and not the C-terminally truncated receptor increased Dub3 transcriptional activity (XREF_FIG), indicating that coactivator recruitment through the C-terminus that contains the AF2 domain is essential to the Esrrb mediated transcriptional response on the Dub3 promoter."
24695638
reach
"ERRbeta knockdown in and DY131 stimulation of mouse ESCs reduces or enhances Dub3 and Cdc25A, respectively, and RNAi mediated inhibition of Dub3 or Cdc25A led these cells to differentiate."
27507929
reach
"To address the specific role of the two splice variants NCoA and SRC1A and NCoA and SRC1E on Esrrb mediated Dub3 transcription, we individually cotransfected each coactivators with Esrrb and measured the activity of a luciferase reporter gene."
24695638
reach
"Surprisingly, we also found an interaction through the Q rich domain, which seemed to convey inhibitory signals since deletion of this region resulted in increased Esrrb mediated Dub3 transcription (XREF_FIG)."
24695638