IndraLab

Statements


USP1 inhibits HYCC1. 5 / 5
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"Thus, we made a conclusion that targeting USP1 could reduce the proliferation of HCC cells.4 DISCUSSION."

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"In contrast, genetic ablation or pharmacological inhibition of USP1 dramatically impaired the phenotypes of HCC cells."

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"Targeting USP1 could decrease the proliferation of HCC cells via cell cycle arrest."

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"To further examine the effect of USP1 inhibition on the growth of HCC cells, we used a specific siRNA to inactivate USP1 and determine whether USP1 inactivation can inhibit the growth of HCC cells."

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"These results suggest that the genetic inactivation of USP1 by siRNA silencing induces similar effects to those of ML-323 by promoting the apoptosis and autophagy of HCC cells."