IndraLab

Statements

Tamoxifen inhibits KCNH2. 3 / 3
1 | 2
drugbank
No evidence text available
15272206
sparser
"Tamoxifen and endoxifen inhibited the hERG channel protein trafficking to the plasma membrane in a concentration-dependent manner with endoxifen being more potent than tamoxifen."
25680947
sparser
"For example, the hERG inhibitory activity of dactinomycin from cytotoxic antibiotics and tamoxifen from endocrine therapy had been validated by in vitro assays. xref , xref Tamoxifen inhibited hERG at −50mV in a concentration-dependent manner with IC 50 value of 1.2 μM. xref Dactinomycin markedly reduced the hERG mRNA levels as well. xref Moreover, amsacrine, an antineoplastic agent used in acute lymphoblastic leukemia, had been confirmed to block hERG in HEK 293 cells with IC 50 values of 209.4 nM. xref Finally, we computationally identified multiple novel hERG blockers by deephERG, such as picamycin and bleommycin."
30715873