IndraLab

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"These results suggest that USP10 deubiquitinase activity is required for its effects in AMPK activation and cellular metabolism.We then explored the mechanism by which USP10 modulates AMPK activation,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"USP10 interacts with AMPK and deubiquitinates AMPKα."

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"USP10 interacts with AMPK and deubiquitinates AMPKalpha."

sparser
"We then explored the mechanism by which USP10 modulates AMPK activation, first by examining whether USP10 directly interacts with AMPK."

reach
"We then explored the mechanism by which USP10 modulates AMPK activation, first by examining whether USP10 directly interacts with AMPK."

sparser
"Thus, USP10 and AMPK form a key feedforward loop ensuring amplification of AMPK activation in response to fluctuation of cellular energy status."

sparser
"Using recombinant proteins, we found that USP10 directly interacted with AMPK α1 and α2 but not the other AMPK subunits ( xref )."

sparser
"USP10 and AMPK can form a key feedforward loop that ensures amplification of AMPK activation in response to fluctuations in cellular energy status ( xref )."

sparser
"Using recombinant proteins, we found that USP10 directly interacted with AMPK α1 and α2 but not the other AMPK subunits ( Figure 2 A)."