IndraLab

Statements

PRNP binds SCN2A. 11 / 12
1 | 11
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"Fourth generation PAMAM dendrimer inhibited formation of PrP Sc in ScN2a cells with IC 50 of 5.5 nM and decreased the PK resistance of the existing PrP Sc in these cells with IC 50 of 9 nM [22,23] ."
15766724
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"PrP with a single point mutation can completely inhibit heterologous PrP formation in ScN2a cells ."
11152275
sparser
"In addition, Rambold et al. [ xref ] identified 142 and its diastereoisomer 144 ( xref ) as potent drugs to interfere with the formation of PrP Sc in ScN2a cells."
28538692
sparser
"The most potent blocking Fab, D18, inhibits PrP formation in ScN2a cells at a concentration of 6nM, whereas R72, a different high-affinity anti-PrP Fab, fails to alter PrP levels at a >400nM concen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11996878
sparser
"Quinacrine, an antimalarial acridine derivative, has been shown to inhibit PrP formation in ScN2a cells with an of 0.3–0.4μM . A comparative analysis using 24 structurally relat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11996878
sparser
"Several porphyrin and phthalocyanine compounds block PrP formation in ScN2a cells ."
11996878
sparser
"Metal-free PcTS blocked PrP formation in ScN2a cells with an of 0.5μM, whereas PcTs-Al was ineffective at a 10μM concentration () ."
11996878
sparser
"These compounds were screened for their ability to block PrP formation in ScN2a cells, resulting in the identification of the inhibitor 2-amino-6-[(2-aminophenyl)thio]-4-(2-furyl)pyridine-3,5-dicarbon[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11996878
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"To demonstrate specificity, radioactive binding to specific sites in crude extracts should not be displaceable by compounds such as quinacrine mustard or PcTS-Al, in accordance with the inability of t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11996878
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"Congo Red (CR, 113 , xref ) was found to inhibit the formation of PrP Sc in cell-free assays back in 1983, and later to prevent the formation and accumulation of PrP Sc in ScN2a cells [ xref , xref ]."
28538692
sparser
"To investigate the efficacy of quinacrine enantiomers, we measured the inhibitory effect of these isomers on PrP(Sc) formation in ScN2a cells. (S)-quinacrine exhibited superior antiprion activity compared with (R)-quinacrine and two generic quinacrines that appear to be racemates."
12808118