IndraLab

Statements

SCN2A binds PRNP. 10 / 10
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sparser
"Quinacrine, an antimalarial acridine derivative, has been shown to inhibit PrP formation in ScN2a cells with an of 0.3–0.4μM . A comparative analysis using 24 structurally relat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11996878
sparser
"To demonstrate specificity, radioactive binding to specific sites in crude extracts should not be displaceable by compounds such as quinacrine mustard or PcTS-Al, in accordance with the inability of t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11996878
sparser
"These compounds were screened for their ability to block PrP formation in ScN2a cells, resulting in the identification of the inhibitor 2-amino-6-[(2-aminophenyl)thio]-4-(2-furyl)pyridine-3,5-dicarbon[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11996878
sparser
"PrP with a single point mutation can completely inhibit heterologous PrP formation in ScN2a cells ."
11152275
sparser
"In addition, Rambold et al. [ xref ] identified 142 and its diastereoisomer 144 ( xref ) as potent drugs to interfere with the formation of PrP Sc in ScN2a cells."
28538692
sparser
"Several porphyrin and phthalocyanine compounds block PrP formation in ScN2a cells ."
11996878
sparser
"Metal-free PcTS blocked PrP formation in ScN2a cells with an of 0.5μM, whereas PcTs-Al was ineffective at a 10μM concentration () ."
11996878
sparser
"Congo Red (CR, 113 , xref ) was found to inhibit the formation of PrP Sc in cell-free assays back in 1983, and later to prevent the formation and accumulation of PrP Sc in ScN2a cells [ xref , xref ]."
28538692
sparser
"The most potent blocking Fab, D18, inhibits PrP formation in ScN2a cells at a concentration of 6nM, whereas R72, a different high-affinity anti-PrP Fab, fails to alter PrP levels at a >400nM concen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11996878
sparser
"To investigate the efficacy of quinacrine enantiomers, we measured the inhibitory effect of these isomers on PrP(Sc) formation in ScN2a cells. (S)-quinacrine exhibited superior antiprion activity compared with (R)-quinacrine and two generic quinacrines that appear to be racemates."
12808118