IndraLab

Statements

USP11 binds LPAR1. 5 / 6
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reach
"To develop small molecules specific for destabilization of LPA1, future studies will focus on drug throughput screening of small molecules to interrupt the interaction between LPA1 and USP11 interaction, thereby leading destabilization of LPA1 and lessening endotoxin induced inflammatory lung injury."
27448760
sparser
"LPA1 is associated with USP11 in quiescent cells, while LPA treatment triggers LPA1 dis-association with USP11 and in turn binding to Nedd4L. Knockdown or inhibition of USP11 reduces LPA1 stability, levels of LPA1, and LPA1-CD14 interaction complex; thereby diminishing both LPA- and LPS-induced inflammatory responses and lung injury in preclinical murine models."
27448760
reach
"In contrast to the LPA increased in the association between LPA1 and Nedd4L, LPA treatment reduced the interaction between LPA1 and USP11 (XREF_FIG d)."
27448760
sparser
"To develop small molecules specific for destabilization of LPA1, future studies will focus on drug throughput screening of small molecules to interrupt the interaction between LPA1 and USP11 interaction, thereby leading destabilization of LPA1 and lessening endotoxin-induced inflammatory lung injury."
27448760
sparser
"In contrast to the LPA-increased in the association between LPA1 and Nedd4L, LPA treatment reduced the interaction between LPA1 and USP11 ( xref d)."
27448760