IndraLab

Statements


RELA increases the amount of TNFAIP3. 3 / 8
2 2 | 3

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"Together these data indicate that NF-kappaB p65 and C/EBPbeta were mediators of LPS induced Tnfaip3 expression in macrophages."

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"RelA also enhanced Tnfaip3 expression following TNFalpha treatment, but significant differences were not detected between wild-type and Thr 435 mutants (XREF_FIG C)."

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"However, when overexpressing TNFAIP3 and PLAU or upon activation of the NFkappaB pathway, all the inhibitory effects of SFE were reversed (XREF_FIG A-D), suggesting that SFE blocked the p65 promotion of TNFAIP3 and PLAU expression to inhibit ESCC cell proliferation and metastasis."