IndraLab

Statements

AKT1 phosphorylates MTOR on S2448. 9 / 17
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"Despite modulation of PRAS40, which regulates the mTOR containing TORC1 complex, mutational activation of PIK3CA or AKT1 did not consistently increase phosphorylation of mTOR at serine 2448 or phosphorylation of mTOR target proteins and their targets, including p70-ribosomal protein S6-kinase (p70S6K), eukaryotic elongation factor 4 binding protein 1 (EIF4EBP1), and ribosomal protein S6."
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"AKT1 also phosphorylates mTOR at S2448, which may be followed by mTOR S2481 autophosphorylation [ xref ]."
30212583
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"The mTORC1 is acutely inhibited by rapamycin, which has been used therapeutically and experimentally as a probe to gain insight into mTORC1 regulation and function. xref The mTORC2 is significantly less sensitive to rapamycin than mTORC1. xref mTORC1 is known to suppress autophagy, which is a key catabolic process. xref The mTOR is phosphorylated by Akt1 at Ser2448 to yield phospho-mTOR (p-mTOR), which regulates ribosome biogenesis and protein synthesis, xref and is also present in the cytoplasm and nucleus, with high p-mTOR expression indicating reduced response to tumor treatment. xref , xref "
29916308
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"MTOR is phosphorylated by Akt1 at Ser2448, leading to downstream signaling by p-mTOR."
29916308
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"MTOR is phosphorylated by Akt1 at Ser2448, leading to downstream signaling by p-mTOR. xref The premise of our study was to examine the regulatory relationship between the mTOR pathway and PKM2."
29916308
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"Next, our results demonstrated that active AKT1 (S473) and p70S6K (T389) phosphorylated S2448 site of mTOR in an in vitro kinase assay."
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"Activated mTOR is phosphorylated at Ser 2448 by AKT1 and functions in mediating cell growth and proliferation [16] ."
22944293
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"AKT1 also phosphorylates mTOR at S2448, which may be followed by mTOR S2481 autophosphorylation [47]."
30212583
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"Protein kinase B (PKB) phosphorylates mTOR at serine 2448 (Ser ), activating this pathway."
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