IndraLab

Statements

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"This study reveals that SLO binds to a class of molecules known as glycosphingolipids on the surface of human cells and that this interaction promotes efficient binding of SLO to cholesterol in the cell membrane and enhances pore formation."
39835825
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"Previous studies have demonstrated a lower sensitivity of anti-SLO in impetigo [33, 34], potentially because of cholesterol binding to SLO [35], and could indicate a potential limitation of using a cohort with invasive disease to predict the infecting etiology in those with uncomplicated BHS cellulitis."
38872850
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"SLO monomers bind to cholesterol on the plasma membrane, followed by oligomerization, insertion into the lipid bilayer, and formation of a protein lined pore of about 30 nm in diameter."
25665445
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"SLO specifically binds to membrane cholesterol and oligomerises, creating a ring structure that inserts into the membrane and makes a large pore ( Sierig et al., 2003; Shatursky et al., 1999 )."
22613563
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"SLO binds to cholesterol in the plasma membrane and oligomerizes to form ~ 30-nm-diameter pores."
| PMC
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"In this study we explore the role for cholesterol binding by SLO in CMT by extracting it from the membrane and by mutating SLO 's cholesterol recognition motif."
25196983
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"SLO binds to cholesterol in cell membranes, forms large 30 nm diameter pores (versus 1-2 nm pores for Cry PFTs), and is an important virulence factor of human-pathogenic streptococci XREF_BIBR."
21408619
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"Like other thiol activated cytolysins, SLO binds to cholesterol present in eukaryotic cell membranes, where it oligomerizes to form transmembrane pores (Sekiya et al., 1993; Palmer et al. 1998)."
11403411
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"The SLO and cholesterol complex induced the chemokine production in proportion to the residual hemolytic activity of the complex."
11911187
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"Our observation of YFP-GPI partitioning into SLO induced endosomes (XREF_FIG) and the fact that SLO interacts with membrane cholesterol during pore formation suggested a role for cholesterol rich membrane domains in this endocytic mechanism."
18316410
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"While there is little doubt that BK channel-forming subunits provide a platform for the recognition of cholesterol and PIP molecules, likely via different molecular sites, the slo1 protein site(s) that binds cholesterol remains to be determined."
36988883
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"At 4degreesC, SLO binds to cholesterol in the plasma membrane."
22952896
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"Cholesterol binding to BK channel-forming proteins involves the central tyrosine of a CRAC domain located at the channel core-cytosolic tail interface."
36783269
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"The pore forming toxin SLO binds to cholesterol molecules present on the eukaryotic cell membrane to create pores and cause cell lysis [XREF_BIBR]."
29099935
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"Once bound to cholesterol, SLO monomers oligomerise into ring-shape structures giving rise to pores of ∼30 nm of diameter ( Duncan and Schlegel, 1975 )."
18299137
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"A possible explanation for these findings is that cholesterol enriched microdomains containing glycosphingolipids in the erythrocyte membrane become occupied by tightly stacked lectin molecules, blocking the interaction between cholesterol and SLO that would otherwise result in penetration of the membrane."
25197935
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"Removal of the maltose binding protein from the SLO fusion products increases the order of the monolayer array of biotinylated SLO bound to cholesterol crystals."
9705878
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"While we did not measure antibiotic levels in the lesions, it is known that SLO can facilitate the delivery of proteins and other molecules into living cells by binding to cholesterol in the membranes[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21798675
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"Low temperatures promote SLO and cholesterol binding on the cell surface."
38261662
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"First, SLO binds to membrane cholesterol and then it is oligomerized to form a pre-pore state and inserted into the lipid bilayer [33-35]."
27362457
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"The rate of SLO diffusion is suggested to be slower than that of SLO binding to cholesterol."
27362457
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"Since a linear relationship between P 30 min and the fraction of cholesterol in a lipid bilayer is maintained as far as P 30 min is above 0.3, the leveling off of P 30 min after 30 min can not be expl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27362457
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"This indicates that the enzymatic oxidation of cholesterol in the lipid bilayer did not progress during 30 min, probably because DTT-activate SLO interacted with cholesterol more strongly than cholest[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27362457
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"SLO can bind cholesterol in the plasma membrane at low temperature (4°C) and form pores in the membrane to allow the permeabilization of biomolecules into cells at high temperature (37°C)."
30976813
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"As there are cell-to-cell differences in membrane cholesterol levels that affect the number of SLO molecules that can bind to the membrane cholesterol to form pores, cell-to-cell variation in the amount of resealed antibody is inevitable."
36601537
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"The effect of the delivery method using streptolysin O (SLO), however, needs to be determined, since SLO binds to cholesterol molecules on cell plasma membrane which may cause damages to cell membrane [XREF_BIBR, XREF_BIBR]."
19341452