IndraLab

Statements

USP14 inhibits degradation. 6 / 6
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"USP14 is closely associated with the proteasome, and an earlier report described that USP14 inhibits the degradation of ubiquitinated proteins by the proteasome ( xref )."
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"USP14, a proteasome‐associated DUB, inhibits the degradation of ubiquitin‐protein conjugates both in vivo and in vitro ."
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"Like Ubp6, Usp14 inhibited the degradation of Ub-cyclin B ( xref )."
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"USP14 inhibited the degradation of YFP-CL1, as overexpression of USP14 increased YFP-CL1 abundance (Supplementary Fig.  xref ), while silencing USP14 accelerated YFP-CL1 degradation (Fig.  xref )."
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"We further detected the change of MDM2-AR interaction using co-immunoprecipitation (co-IP), and found that USP14 inhibition or silence increased the binding of MDM2 to AR ( xref ), suggesting that USP14 inhibits the degradation of AR by decreasing the expression and phosphorylation of MDM2."
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"It is possible that USP14 can promote or inhibit degradation depending on the individual substrate in question."
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