IndraLab

Statements

CALR binds JMJD6. 6 / 6
| 6
sparser
"The cytoplasmic calreticulin binds to phosphatidylserine in the inner leaflet of the plasma membrane from where it is externalized as the plasma membrane loses its asymmetry."
25126089
sparser
"Calreticulin can bind phosphatidylserine ( xref ), and Wijeyesakere et al. ( xref ) showed that calreticulin directly bound phosphatidylserine exposed on apoptotic cells via its C-terminal acidic region, and enhanced phagocytosis of apoptotic fibroblasts by peritoneal macrophages, which was dependent on this phosphatidylserine-binding region."
34177884
sparser
"The second suggested pathway, relevant to apoptotic cells, involves the binding of cytosolic calreticulin to phosphatidylserine on the inner leaflet of the plasma membrane prior to apoptotic exposure of phosphatidylserine-calreticulin complexes on the cell surface ( xref )."
21670312
sparser
"Calreticulin binds to phosphatidylserine on the surface of apoptotic cells via a calcium and C-domain-dependent pathway and with phagocytes via lectin and P-domain-dependent interaction that may involve its generic polypeptide-binding site ( xref ) ( xref )."
34050865
sparser
"Calreticulin can bind phosphatidylserine ( xref ), and so may signal to phagocytes either alone or in association with exposed phosphatidylserine."
34177884
sparser
"Calreticulin can bind in a Ca 2+ -dependent manner to phosphatidylserine (PS) with high affinity (K D = 1.5 × 10 −5 M) [ xref , xref ]."
32443761