IndraLab

Statements

ACVR1B binds ACVR2A. 6 / 6
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"Follistatin acts by masking the activin regions crucial for the interaction with ActRII and ALK4. xref "
33194149
reach
"Also in the Activin : ActRII complex no direct contact between the two receptor ECDs was observed with the closest proximity being 31A, however, whether or not receptor interaction between ActRII and ActRIIB and ALK4 occur, awaits structural data with the ALK4 extracellular domain."
21353878
reach
"In contrast to TGFbeta, TRAF6 recruitment to the ALK4 and ActRII complex was significantly decreased early after infection although it was restored at 18 hpi (XREF_FIG)."
30891432
reach
"ActRII binds to activin in combination with ALK4, but also binds both BMP2 and BMP7 in the presence of BMP type I receptors (Carcamo et al., 1994; Yamashita et al., 1995; Willis et al., 1996)."
10831835
reach
"ALK4 and ActRII interactions increased within 30 ' post infection and then decreased by 2 hpi (XREF_FIG and XREF_SUPPLEMENTARY)."
30891432
reach
"The phosphorylation as a consequence of the interaction between ActR-IB and ActR-II allows ActR-IB to spread the signal transduction, which is the same as mechanism of activation of the TGF-receptor ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11261590