IndraLab

Statements

GRB2 binds SOS1 and GRB2. 3 / 3
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"This is based on the experimental dissociation constant,, for the formation of the Grb2, Sos1, and Grb2 complex from the Grb and Sos1 complex."
22022247
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"Based on the multiplicity of Sos1 : Grb2 and LAT : Grb2 interactions, it was hypothesized that the Grb2, Sos1, and Grb2 complex could nucleate LAT oligomerization."
24222714
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"This equation can be rewritten as : (9) or in other words : (10) where is the effective equilibrium constant for the binding of a Grb2 from solution to a Grb2 and Sos1 complex to form a Grb2, Sos1, and Grb2 complex : (11) To make predictions about the binding of Grb2 to the complete polyproline rich domain of Sos1 (1117-1319) we must estimate the values of the unknown equilibrium constants for the binding of the N- and C-SH3 domains of Grb2 to RP on Sos1."
22022247