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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

RAS binds CCND1, CDK4, and NF1. 1 / 1

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"The remaining patients that have neither gene mutation typically have de-regulated kinases including amplification and overexpression of PAK1 [ xref , xref ], inactivation of the NF-1 tumor suppressor [ xref ], loss of NF-1 associated with RAS activation [ xref , xref ] and cell cycle aberrations such as CCND1 and CDK4 amplification [ xref ]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...