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"A-type potassium channels play a pivotal role in modulating neuron excitability; in fact, their downregulation may increase pain sensation. xref The A-type potassium channel Kv4.2 has been detected in DRG neurons and appears to be responsible for the transient A-type potassium current ( I A ) recorded in small DRG neurons. xref Kv4.2 is a known substrate for ERK1/2. xref The phosphorylation of Kv4.2 by ERK1/2 in dorsal horn neurons underlies the induction of central sensitisation and is critical for pain modulation. xref "