IndraLab

Statements


USP10 binds USP7 and NHE3. 4 / 4
| 4

sparser
"We showed that FSK attenuated the interaction of USP7 and USP10 with NHE3, resulting in increased ubiquitination of NHE3."

sparser
"NHE3 is inhibited by protein kinase A. Activation of PKA by forskolin decreased the binding of USP7 and USP10 to NHE3, while increasing ubiquitination of NHE3."

sparser
"The binding of USP7 and USP10 to NHE3 was confirmed by co-immunoprecipitation."

sparser
"To confirm that USP7 or USP10 interact with NHE3, we performed immunoprecipitation of NHE3 using P5D4 or IgG as a negative control, followed by immunoblotting for USP7 or USP10."