IndraLab

Statements

USP22 decreases the amount of SOX2. 8 / 8
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"In mouse ES cells, Usp22 represses the transcription of the pluripotency factor Sox2, thereby promoting differentiation [XREF_BIBR]."
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"USP22 is known to bind to the promoter region of Sox2 and negatively regulates Sox2 transcription in embryonic stem cells (ESCs) 47."
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"Loss of Usp22 occupancy at the Sox2 locus is associated with elevated levels of H2Bub and increased transcription of Sox2."
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"In addition, USP22 occupies the Sox2 promoter and hydrolyzes mono-ubiquitin from ubiquitinated H2B (uH2B), and blocks transcription of the Sox2 locus."
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"DUBs that have been reported to control developmental processes through deubiquitylating H2B include USP44, which represses genes involved in lineage commitment during mESC maintenance [XREF_BIBR], and USP22, which specifically inhibits expression of the pluripotency factor SOX2 during hESC differentiation [XREF_BIBR]."
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"USP22 has been found to be located directly on the Sox2 promoter and catalyzes deubiquitination of H2B and attenuates Sox2 transcription."
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"USP22 is located directly on the Sox2 promoter and negatively regulates Sox2 transcription in ESCs [XREF_BIBR]."
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"In the recent study by Sussman et al., USP22 was shown to repress the expression of the Sox2 locus that encodes one of the core transcriptional regulators of ES-cell pluripotency (Sussman et al., 2013[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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