IndraLab

Statements

DIABLO leads to the dephosphorylation of CYLD. 3 / 3
| 3
reach
"Disruption in RIPK1 ubiquitination is also known to disrupt IKK activity , and therefore we hypothesized that SMAC mimetics could also reduce IKK activity and CYLD phosphorylation."
32024820
reach
"We provide evidence to show that SMAC mimetics, which are being evaluated as antitumor agents, function similarly to the IKK inhibitors to disrupt CYLD phosphorylation."
32024820
reach
"SMAC mimetics can similarly disrupt CYLD phosphorylation and lead to ATLL cell death through reduction of RIPK1 ubiquitination, which is CYLD dependent."
32024820