IndraLab

Statements

Modified COPS5 increases the amount of RANBP9. 2 / 2
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"Interestingly, COPS5 overexpression increased RanBP9 levels in the brain, which, in turn, led to increased amyloidogenic processing of APP, as reflected by increased levels of sAPPbeta and decreased levels of sAPPalpha."
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"Finally, COPS5 levels were increased significantly in AD brains and APDeltaE9 transgenic mice, and overexpression of COPS5 strongly increased RanBP9 protein levels by increasing its half-life."
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