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Modified TP53 increases the amount of TP53. 37 / 37
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"AGGF1 antagonizes MDM2 function to inhibit p53 ubiquitination, increases the acetylation, phosphorylation, stability and expression levels of p53, activates transcription of p53 target genes, and regulates cell proliferation, cell cycle, and apoptosis."
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"The current study demonstrated that the expression levels of EZH2 and P53 in tumor tissue and the proportion of cases with double positive expression significantly increased with increasing clinical stages of cancer, also confirming up-regulated expression of EZH2 and P53 with increasing stages."
25275664
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"Camptothecin and doxorubicin treatments in RT-4 cells or transient overexpression of p53 into p53-mutant HT1376 cells induced p53 and BTG2 expression."
29239139
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"An increased level of TP53 targeting miRNAs in GC B cells such as miR-21, miR-25 and miR-200c could promote an additional control level of TP53 expression after the activation of the DNA damage response."
28107180
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"Overexpression of p53 activates transcription of p53 effector genes, causes growth inhibition and induced apoptosis."
11313982
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"Basal levels of wild-type p53 can stimulate PGC-1alpha expression and mitochondrial biogenesis in mice, while severe cellular stress associated with telomere dysfunction and increased p53 levels can repress both PGC-1alpha and PGC-1beta expression [XREF_BIBR, XREF_BIBR]."
27003724
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"Next, to investigate whether RITA induced senescence depends on p53 status, we treated the stable-p53-knockdown cell lines HN30-shp53 and HN31-shp53 with RITA and found that knockdown of p53 protein expression markedly reduced both the expression and phosphorylation of p53 (XREF_FIG)."
25119136
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"The elevated levels of p53 further up-regulate expression of p21 and that of the pro apoptotic p53 target genes BAX and PUMA in breast cancer cells."
19123943
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"The ERalpha involvement in the ACH induced increase in p53 level is also supported by the inability of ACH to affect p53 gene expression in ERalpha negative MDA-MB-231 breast cancer cells."
30148119
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"36 Here, we observed enhanced p53 levels in Poly (I : C)-treated mice that paralleled increases in Mysm1 expression, and that there was enhanced p53 transcription in Mysm1 -/- HSCs."
27277682
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"Interestingly, we found that, overexpression of exogenous p53 was able to induce transcription of p53 dependent p53R2-luc promoter, likely overcoming the inhibitory effect generated by HIPK2 depletion[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The induced expression of p53 in 1j treated cells was found similar to cisplatin exposed cells, However, unlike cisplatin, 1j molecule did not induce the expression of p53 in NKE cells."
27380262
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"In this study, we found that p53 was dramatically upregulated by Ad-DIRAS3 infection and that the concurrent re-expression of DIRAS3 and p53 induced an even higher level of p53 expression."
33038921
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"Furthermore, hydrogen peroxide (H 2 O 2), a well-known inducer of p53 expression (Pluquet and Hainaut, 2001), failed to induce p53 expression in GT1-7 neurons according to our preliminary results (dat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12927367
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"As shown in Figure XREF_FIG (g), expression of p53 strongly induced mRNA expression of both FUCA1 and a representative p53 target gene, PHLDA3, in p53-null Saos2 cells."
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"The comparisons of p53 expression among indicated groups found SIRT1 knockdown and upregulated SIRT1 significantly increased and inhibited the expression of p53, respectively (XREF_FIG)."
25147862
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"As demonstrated in XREF_FIG, irradiation of the wild-type p53 expressing HCT116 cells markedly increased p53 levels, which were also upregulated by treatment with valproic acid."
28454438
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"For example high levels of p53 expression in embryonic development causes cell death in neuronal cells and retina, moderate levels of p53 expression causes replicative senescence in hematopoietic progenitor cells, whereas low but chronic level of p53 expression causes senescence in pneumocytes and fibrosis in lung and liver tissue [XREF_BIBR]."
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"In contrast, the p53 antagonizing oncogene mdm2 was scarcely expressed at 0-1 h post-irradiation, but was drastically enhanced at 2-3 h post-irradiation, eventually paralleling p53 expression."
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"This study used a different mode to effect changes in p53 expression, i.e. increasing p53 expression as opposed to reducing baseline expression, and this may affect cellular responses to radionuclide [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23062949
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"As expected, dn p53 expression in HFKs caused increased p53 levels, presumably by stabilizing and inactivating endogenous wild type TP53 (Gottlieb et al., 1994)."
29427865
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"In addition, bryostatin 5 increased the expression of P53 upregulated modulator of apoptosis (PUMA) and slightly increased P53 expression."
24036350
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"Similarly, overexpression of p53 25,26,53,54, but not wild-type p53, in p53 +/+ MEFs significantly enhanced expression of select p53 target genes (XREF_FIG)."
25119037
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"P53 -/- hepatocytes expressing inducible p53 and primary wild type hepatocytes were treated to induce p53 expression."
23714159
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"We also demonstrated that a negative regulator of p53 transcription, RBP-Jkappa (CBF1), can also bind to the same regulatory site approximately 960 bp upstream of the p53 promoter and repress p53 expr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24418698
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"Due to the low transduction rate of p53 gene introduction via Adp53 vector, several types of cancer specific p53 expressing conditionally replicating adenovirus vectors (known as conditionally replicating Adp53 [CRAdp53] vectors), which can induce higher p53 expression and stronger antitumor effects have been developed [XREF_BIBR]."
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"In fact, the interaction between the two is a two way street, with several miRNAs being able to regulate p53 expression either through direct targeting, or through regulation of other proteins that in turn modulate p53 expression and function."
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"Such a lack of p53 expression in EA cells might be due to a loss of intrinsic capacity to increase p53 levels in response to DNA damage or to overexpression of proteins that promote the breakdown of p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10741303
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"Suppression of p53 expression by siRNA inhibited the expression of p53 as well as its target genes along with the prevention of apoptosis induction."
28098861
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"Presumably, the reductions in mRNA levels were caused by the decrease in expression of p53 proteins from late torpor to arousal, resulting in the restabilization of p53 downstream gene expressions."
26843984
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"TP53 expression was only slightly increased by fosaprepitant in IMR5 cells, suggesting changes in TP53 activity rather than TP53 levels."
27888795
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"Since C/EBPbeta -2 binds to this region in a cell-cycle regulated manner, C/EBPbeta -2 thus likely participates in the cell-cycle regulated modulation of the Wrap53beta promoter as well.It was recentl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24418698
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"While somewhat higher p21 levels were observed in some Mdm2 Y487A and Y487A tissues, potentially indicative of higher p53 activity, in Mdm2 Y487A and Y487A MEFs, elevated levels of p53 did not lead to increased levels of the p53 targets p21 and Apaf1, suggesting that p53 transcriptional activity is not increased in Mdm2 Y487A and Y487A MEFs."
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"Nutlin 3a treatment of wild type p53 expressing cultured cancer cells increases p53 levels and causes p53 mediated transactivation, cell cycle arrest, and apoptosis [XREF_BIBR]."
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"Moreover, the enhanced mRNA expression of p53 may increase the expression levels of p53 and EGFP in the group transfected with DDC and pp53-EGFP complexes compared to lipofection complexes."
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"After 1.5 h of treatment with TGRL lipolysis products (TL1.5), p53 expression was significantly increased (XREF_FIG), while the treatment with T or L did not significantly alter p53 expression compared to the media control group."
26709509
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"The decrease in p53 levels could be reversed by the addition of proteasome inhibitor MG132, suggesting that USP10 regulates p53 levels in a proteasome dependent manner."
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