IndraLab

Statements

USP14 activates pathogenic aggregates Tau protein Alzheimer disease TDP-43. 2 / 2
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eidos
"Usp14 inhibitors are able to increase the degradation rate of the pathogenic aggregates of Tau protein ( Alzheimer 's disease ) as well as TDP-43 ( amyotrophic lateral sclerosis ) , opening new exciting therapeutic approaches ."
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eidos
"Usp14 inhibitors are able to increase the degradation rate of the pathogenic aggregates of Tau protein ( Alzheimer 's disease ) as well as TDP-43 ( amyotrophic lateral sclerosis ) , opening new exciting therapeutic approaches.3 Finally , a new set of drugs , called degraders ,16 which have the ability to trigger selective degradation of target proteins via UPS-recruiting E3 ligases , represent an invaluable strategy for basic research , as well as drug discovery and development of new therapies ."
33681549